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PUBLICATIONS

A: Journal article:  

  1. Nuthalapati, K., Vankayala, R., Chiang, C. S., and *Huang, K. C.  Unprecedented Theranostic LaB6 Nanocubes-Mediated NIR-IIb Photodynamic Therapy to Conquer Hypoxia-Induced Chemoresistance. Advanced Functional Materials 2020 (12 July; Online; https://doi.org/10.1002/adfm.202002940).  

  2. Nuthalapati, K., Vankayala, R., Chiang, C. S., and *Huang, K. C. Size and shape effects of near-infrared light-activatable Cu-2(OH)PO4 nanosstructures on phototherapeutic destruction of drug-resistant hypoxia tumors. Particle and Particle systems characterization (Part. Part. Syst. Charact.), 37(5): 2000001 (1 to 12), 2020 (Apr. 20, 2020; https://doi.org/10.1002/ppsc.202000001). 

  3. Fu, S. Y., Wang, C. C., Chen, F. H., Yu, C. F., Hong, J. H.,  and *Chiang, C. S. Sunitinib Treatment-elicited Distinct Tumor Microenvironment Dramatically Compensated the Reduction of Myeloid-derived Suppressor Cells. In Vivo 34 (3): 1141-1152, 2020 (May-June; DOI:10.21873/invivo.11886). 

  4. Su, Y. L., Kuo, L. W., Hsu, C. H., Chiang, C. S., Lu, Y. J., Chang, S. H., *Hu, S. H. Rabies virus glycoprotein-amplified hierarchical targeted hybrids capable of magneto-electric penetration delivery to orthotopic brain tumor. J. Controlled Release 321:159-173,  2020 (Feb. 8 online, https://doi.org/10.1016/j.jconrel.2020.02.018 ). 

  5. Wu, S. Y. and *Chiang, C. S. Distinct role of CD11b+Ly6G-Ly6C- myeloid-derived cells on the progression of the primary tumor and therapy-associated recurrent brain tumor. Cells 9 (1):51, 2020 (Dec. 20, 2019 Accepted,  https://www.mdpi.com/2073-4409/9/1/51/htm 

  6. Paalme, V., Rump, A., Mädo, K., Teras, M., Truumees, B., Aitai, H., Ratas, K., Bourge, M., Chiang, C. S., Ghalali, A., Tordjmann, T., Teras, J., Boudinot, P., Kanellopoulos, J. M., *Boudinot, S. R.. Human peripheral blood eosinophils express high level of the purinergic receptor P2X4. Front. Immunol. 10:2074,  2019 (Aug. 16, Accepted, https://doi.org/10.3389/fimmu.2019.02074).  

  7. Liu, C. C., Yu, C. F., Wang, S. C., Li, H. Y., Lin, C. M., Wang, H. H., Abate, C., and *Chiang, C. S. Sigma-2 receptor/TMEM97 agonist PB221 as an alternative drug for brain tumor. BMC Cancer 19 (1): 473 ~ 482, 2019 (May 20; https://doi.org/10.1186/s12885-019-5700-7) 

  8. Huang, R.Y., Lin, Y.H., Lin, S.Y., Li, Y.N., Chiang, C. S., and *Chang, C. W.  Magnetic ternary nanohybrids for nonviral gene delivery of stem cells and applications on cancer therapy. Theranostics 9(8): 2411-2423, 2019 (DOI: 10.7150/thno.29326). 

  9. Lin, C. M., Yu, C. F., Huang, H. Y., Chen, F. H., Hong, J. H.,  and *Chiang, C. S. Distinct tumor microenvironment at tumor edge as a result of astrocyte activation is associated with therapeutic resistance for brain tumor. Front. Oncol. 9 : 307, 2019 (26 April; DOI:10.3389/fonc.2019.00307) 

  10. Sung, S. Y., Su, Y. L., Cheng, W., Hu, P. F., Chiang, C. S., Chen, W. T., and *Hu, S. H. Graphene quantum dots-mediated theranostic penetrative delivery of drug and phtolytics in deep tumors by targeted biomimetic nanosponges. Nano Lett.,  19 (1): 69-81, 2019 (Jan. 9; DOI: 10.1021/acs.nanolett.8b03249 .). 

  11. Liu, C. C., Lin, W. W., Wu, C. C., Hsu, S. L., Wang, C. Y., Chung, J. G., and *Chiang, C. S.. Lauryl gallate induces apoptotic cell death through caspases-dependent pathway in human glioma cancer U87 cells in vitro. In Vivo 32 (5): 1119-1127, 2018 (Sep-Oct; doi: 10.21873/invivo.11354 ). 

  12. Chang, R. S., Chen, C. S., Huang, C. L., Chang, C. T., Cui, Y., Chung, W. J., Shu, W. Y., Chiang, C. S., Chuang, C. Y., and *Hsu, I. C. Unexpected dose response of HaCaT to UVB irradiation.  In Vitro Cellular and Developmental Biology-Animal (In Vitro Cell Dev Biol Anim) 54 (8): 589-599, 2018 (Sep.)

  13. Liu, T.-I., Yang, Y.-C., Chiang, W.-H., Hung, C.-K., Tsai, Y.-C., Chiang, C. S., Lo, C.-L., *Chiu, H.-C. Radiotherapy-Controllable Chemotherapy from ROS-Responsive Polymeric Nanoparticles for Effective Local Dual Modality Treatment of Malignant Tumors. Biomacromolecules, 19 (9): 3825-3839, 2018 (July)(DOI:10.1021/acs.biomac.8b00942)

  14.  Lin, K. C., Lin, M. W., Hsu, M. N., Chen, G. Y., Chao, Y. C., Tuan, H. Y., Chiang, C. S., and *Hu, Y. C. Graphene oxide sensitizes cancer cells to chemotherapeutics by inducing early autophagy events, promoting nuclear trafficking and necrosis. Theranostics 8(6): 2477-2487, 2018 (May 4, Epub) 

  15. Chiu, H. T., Chen, C. H, Lin, M. L., Su, C. K., Sun, Y. C., Chiang, C. S., and *Huang, Y. F. Bioprosthesis of core-shell glold nanorod/serum albumin nanoimitation: a half-native and half-artificial nanohybrid for cancer theranostics. Chem. Mater. 30(3): 729-747, 2018 (Feb. 13). (DOI: 10.1021/acs.chemmater.7b04127).

  16. Yu, C. F., Chen, F. H., Lu, M. H., Hong, J. H., and *Chiang, C. S. Dual roles of tumor cells-derived matrix metalloproteinase 2 on brain tumor growth and invasion. Br. J. Cancer 117 (12): 1828-1836.  2017 (Dec. 5) (DOI:10.1038/bjc.2017.362)  

  17. Jiang, P. S., Tsai, H. Y., Drake, P., Wang, F. N., and *Chiang, C. S. Gadolinium-doped iron oxide nanoparticles induced magnetic field hyperthermia combined with radiotherapy increases tumor response by vascular disruption and improved oxygenation. International J. Hyperthermia. 33(7): 770-778,  2017 (Oct.) 

  18. Chiu, H. T., Su, C. K., Sun, Y. C., Chiang, C. S., and *Huang, Y. F. Albumin-gold nanorod nanoplatform for cell-mediated tumoritropic delivery with homogenous chemodrug distribution and enhanced retention ability. Theranostics 7(12): 3034-3052, 2017 (Aug. 26)

  19. Kuthala, N., Vankayala, R., Li, Y. N., Chiang, C. S., and *Huang K. C. Engineering novel targeted boron-10 enriched theranostic nanomedicine to combat against murine brain tumors via MR Imaging-guided boron neutron capture therapy. Advanced Materials 29 (31): 170850 (1-10), 2017 (Aug. 15) (DOI: 10.1002/adma.201700850). 

  20. Huang, W. C., Lu, I. L., Chiang, W. H., Lin, Y. W., Tsai, Y. C., Chen, H. H., Chang, C. W., Chiang, C. S., and  *Chiu, H. C. Tumortropic adipose-derived stem cells carrying smart nanotherapeutics for targeted delivery and dual-modality therapy of orthotopic glioblastoma. J. Controlled Release,  254: 119-130, 2017 (May 28). 

  21. Chang, E. L., Ting, C. Y., Hsu, P. H., Lin, Y. C., Liao, E. C., Huang, C. Y., Chang, Y. C., Chang, H. L., Chiang, C. S., Liu, H. L., Wei, K. C., Fan C. H., and *Yeh, C. K. Angionenesis-targeting microbubbles combined with ultrasound-mediated gene therapy in brain tumors. J. Controlled Release,  255:164-175, 2017 (June 10). 

  22. Su, Y. L., Yu, T. W., Chiang, W. H., Chiu, H. C., Chun-Hsiang Chang, Chiang, C. S., and *Hu, S. H. Hierachically targeted and penetrated delivery of drugs to tumors by size-changeable graphene quantum dot nanoaircrafts for photolytic therapy.  Advanced Functional Materials 27(23): 1700056, 2017 (June).  

  23. Wang, S. C., Lai, K. R., Li, C. Y., Chiang, C. S., Yu, G. Y., Sakamoto, N., Tu, W. Y., Hsieh, M. H. ,Huang, J. F., Chuang, W. L., Dai, C. Y., *Yu, M. L. The paradoxical effects of different hepatitis C viral loads on host DNA damage and repair ability. PLoS One 12(1): e0164281, 2017 (Jan.).

  24. Vijayaraghavan, P., Chiang, C. S., Chiang, H. K., Li, M. L., and *Hwang, K. C. Multi-branched plasmonic gold nanoechinus-based triple modal bioimaing: an efficient NIR- to –NIR up and down-conversion emission and photacoustic imaging. Adv. Mater. Techol. 1(7): 1600107 (DOI:10.1002/admt.201600107), 2016 (Oct).  (Cover picture)

  25. Su, Y. L., Chen, K. T., Hsu, Y. C., Sung, S. Y., Hsu, R. S., Chiang, C. S., and  *Hu, S. H.   The Penetrated Delivery of Drug and Energy to Tumors by Lipo-Graphene Nanosponges for Photolytic Therapy.  ACS Nano 10(10): 9420 – 9433, 2016 (Oct.) 

  26. Kalluru, P., Vankayala, R., Chiang, C. S., and *Huang, K. C. Unprecedented? All-in-one? Lanthanide-doped mesoporous silica frameworks for fluorescence/MR imaging and combination of NIR light triggered chemo-photodynamic therapy of tumors. Advanced Functional Materials 26(43): 7908–7920, 2016 (Nov. 15).  

  27. Chen, F. H., Wang, C. C., Liu, H. L., Fu, S. Y., Yu, C. F., Chang, C., Chiang, C. S., and *Hong, J. H. Decline of tumor vascular function as assessed by DCE-MRI is associated with poor responses to radiotherapy and chemotherapy. Int J Radiat Oncol Biol Phys. 9 (5): 1495-503, 2016 (Aug. 1). 

  28. Kalluru, P., Vankayala, R, Chiang, C. S., and *Huang, K. C. Nano-graphene oxide-mediated in vivo fluorescence imaging and bimodal photydymanic and photothermal destruction of tumors. Biomaterials 95: 1-10, 2016 (July) 

  29. Yang, Y. C. and *Chiang, C. S. Challenges of using high-dose fractionation radiotherapy in combination therapy. Front. Oncol. 6: 165-172, 2016 (30 June; http://dx.doi.org/10.3389/fonc.2016.00165) 

  30. Lin, C. T., Lin, I. C., Sung, S. Y., Su, Y. L., Huang, Y. F., Chiang, C. S., and *Hu, S. H. Dual-Targeted Photopenetrative Delivery of Multiple Micelles/Hydrophobic Drugs by a Nanopea for Enhanced Tumor Therapy. Advanced Functional Materials 26(23): 4169–4179, 2016 (June 20).  

  31. Huang, W. C., Shen, M. Y., Chen, H. H., Lin S. C., Chiang, W. H., Wu, P. H., Chang, C. W., Chiang, C. S., and *Chiu, H. C. Monocytic delivery of therapeutic oxygen bubbles for dual-modality treatment of tumor hypoxia. J. Controlled Release,  220: 738-750, 2015 (Dec.).

  32. Jiang, P. S., Yu, C. F., Yen, C. Y., Woo, C. W., Lo, S. H., Huang, Y. K., Hong, J. H., and *Chiang, C. S. Irradiation enhances the ability of monocytes as nanoparticle carrier for cancer therapy. PLoS One 10(9): e0139043, 2015 (Sep.). 

  33. Vankayala, R., Kuo, C. L., Nuthalapati, K., Chiang, C. S., *Hwang, K. C. Nucleus-targeting gold nanoclusters for simultaneous in vivo fluorescence imaing, gene delivery, and NIR-light activated photodynamic therapy.  Avanced Functional Materials 25: 5934–5945, 2015 (Dec.). (IF: 11.8 (12/259 in MATERIALS SCIENCE, MULTIDISCIPLINARY)

  34. Huang, W. C., Chiang, W. H., Cheng, Y. H., Lin W. C., Yu, C. F., Yen, C. Y., Yeh, C. K., Chern, C. S., *Chiang, C. S., *Chiu, H. C. Tumortropic monocyte-mediated delivery of echogenic polymer bubbles and therapeutic vesicles for chemotherapy of tumor hypoxia. Biomaterials 71: 71-83, 2015 (Aug.). IF: 8.557  (1/32 in MATERIALS SCIENCE, BIOMATERIALS)

  35. Vijayaraghavan, P., Vankayala, R., Chiang, C. S., Sung, H. W., and *Hwang, K. C. Complete destruction of deep-tissue buried tumors via combination gene silencing and gold nanoechinus-mediated photodynamic therapy. Biomaterials 62:13-23, 2015 (Sep.). IF: 8.557  (1/32 in MATERIALS SCIENCE, BIOMATERIALS)

  36. Fan, J. W., Vankayala, R., Chang, C. L., Chang, C. H., Chiang, C. S., *Hwang, K. C. Preparation, cytotoxicity and in vivo bioimaing of highly luminescent water-soluble silicon quatum. Nanotechnology 26 (21):215703 , 2015 (May). IF: 3.821  (40/259 in MATERIALS SCIENCE, MULTIDISPLINARY)

  37. Chen, G. Y., Meng, C. L., Lin, K. C., Tuan, H. Y., Yang, H. J., Chen, C. L., Li, K. C., Chiang, C. S., *Hu, Y. C. Graphene oxide as a chemosensitizer: Diverted autophagic flux, enhanced nuclear import, elevated necrosis and improved antitumor effects. Biomaterials 40:12-22, 2015 (Feb.). IF: 8.557  (1/32 in MATERIALS SCIENCE, BIOMATERIALS)

  38. Chung, W. J. , Cui, Y., Huang, F. Y. J., Tu, T. H., Yang, T. S., Lo, J. M., Chiang, C. S., and *Hsu, I. C. 99mTc Pyrene Derivative Complex Causes Double-Strand Breaks in dsDNA Mainly through Cluster-Mediated Indirect Effect in Aqueous Solution. PLoS One 9(9): e108162, 2014 (Sep.). IF: 3.534 (8/55 in MULTIDISPLINARY SCIENCES)

  39. Huang, C. Y., Chang, C. W., Chen, C. R., Chuang, C. Y., Chiang, C. S., Shu, W. Y., Fan, T. C., and *Hsu, I. C. Extremely low-frequency electromagnetic fields cause G1 phase arrest through the activation of the ATM-Chk2-p21 pathway. PLoS One 9(8): e104732, 2014 (Aug. 11). IF: 3.534 (8/55 in MULTIDISPLINARY SCIENCES)

  40. Vankayala, R., Chiang, C. S., Chao, J. U., Yuan, C. J., and Lin, S. Y., and *Hwang, K.  C. A general strategy to achieve ultra-high gene transfection efficiency using lipid-nanoparticle composites.  Biomaterials. 35(28): 8261-8271, 2014. IF: 8.557  (1/32 in MATERIALS SCIENCE, BIOMATERIALS)

  41. Vijayaraghavan, P., Liu, C. H., Vankayala, R., Chiang, C. S. and *Hwang, K.  C. Designing multi-branched gold nanoechinus for NIR light activated dual modal photydynamic and phtothermal therapy in the second biological window  Advanced Materials. 26: 6689-6695, 2014 (Oct). IF: 15.409 (6/251 in MATERIALS SCIENCE, MULTIDISPLINARY)(Highlithed by Asian Scientist Magazine)

  42. Yu, C. F., Lin, C. M., Wang, S. C., Chen, F. H., Hong, J. H., Tsai, C. S., Yang, Y. C., and *Chiang, C. S. Effects of pre-irradiation and SDF-1 suppression on the progression of murine astrocytoma cells grown in different stromal beds Inter J. Radiat. Biol. 90 (12): 1162-1168, 2014 (Dec)  IF:1.837 (3/33 in NUCLEAR SCIENCE & TECHNOLOGY)

  43. Vankayala, R., Lin, C. C., Kalluru, P., Chiang, C. S. and *Hwang, K.  C. Gold nanoshells-mediated biomodal photodynamic and photothermal cancer treatment using ultra-low doses of near infra-red light.  Biomaterials. 35(21): 5527-5538, 2014 (July). IF: 8.557  (1/32 in MATERIALS SCIENCE, BIOMATERIALS)

  44. Vankayala, R., Huang, Y. K., Kalluru, P., Chiang, C. S. and *Hwang, K.  C. First demonstration of gold nanorods-mediated photodynamic therapeutic destruction of tumors via near infra-red light activation.  Small, 10 (8): 1612 – 1622,  2014 (Apr)  IF: 7.514 (17/251 in MATERIALS SCIENCE, MULTIDISPLINARY) (Highlighted by Nanowerk, Future Med Chem. (2014 6(4), 370 and The #1 Antibody Resource website)

  45. Vankayala, R., Kalluru, P., Tsai, H. H., Chiang, C. S. and *Hwang, K.  C. Effects of surface functionality of carbon nanomaterials on short-term cytotoxicity and embryoic development in zebrafish.  J. Mater. Chem. B. 2(8): 1038-1047, 2014 (Jan). IF: 6.108 (20/241 in MATERIALS SCIENCE, MULTIDISPLINARY)

  46. Kalluru, P., Vankayala, R., Chiang, C. S.‍‍ and *Hwang, K. C. Photosensitization of Singlet Oxygen and In vivo Photodynamic Therapeutic Effects Mediated by PEGylated W18O49 Nanowires.  Angew. Chem. Int. Ed.  (ANGEWANDTE CHEMIE-INTERNATIONAL EDITION). 52:12332-12336, 2013 (Nov.).  IF: 13.734 (7/152 in CHEMISTRY, MULTIDISPLINARY)(Cover Page Article)

  47. Vankayala, R., Kuo, C. L., Sagadevan, A., Chen, P. H., Chiang, C. S.‍‍ and *Hwang, K. C. Morphology dependent photsensitization and formation of singlet oxygen (1Δg) by gold and silver nanoparticles and its application in cancer treatment. J. Mater. Chem. B. 1 (35): 4379-4387,  2013 (Sep. 21). IF: 6.108 (20/241 in MATERIALS SCIENCE, MULTIDISPLINARY)(selected as HOT article by editor for 2013)

  48. Chang, C. W., Chen, C. R., Huang, C. Y., Shu, W. Y., Chiang, C. S., Hong, J. H. and *Hsu, I. C. Comparative Transcriptome Profiling of an SV40-Transformed Human Fibroblast (MRC5CVI) and Its Untransformed Counterpart (MRC-5) in Response to UVB Irradiation. PLoS One 8(9): e73311, 2013 (Sep. 11). IF: 3.534 (8/55 in MULTIDISPLINARY SCIENCES)

  49. Wang, S. C., Yu, C. F., Hong, J. H., Tsai, C. S. and *Chiang, C. S. Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis. PLoS One 8(8): e69182, 2013 (Aug. 5). IF: 3.534 (8/55 in MULTIDISPLINARY SCIENCES)

  50. Chen, F. H., Fu, S. Y., Yang, Y. C., Wang, C. C., *Chiang, C. S. and *Hong, J. H. Combination of Vessel-Targeting Agents and Fractionated Radiation Therapy: The Role of the SDF-1/CXCR4 Pathway. Int J Radiat Oncol Biol Phys. 86 (4): 777-784, 2013 (June). IF: 4.176 (14/121 in RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING)

  51. Chen, J. J., Fu, S. Y., Chiang, C. S., Hong, J. H. and *Yeh, C. K. A preclinical study to explore vasculature differences between primary and recurrent tumors using ultrasound doppler imaging. Ultrasound in Medicine & Biology 39(5):860-869, 2013 (May).  IF: 2.455 (4/41 in Acoustics)

  52. Yu, C. F., Hong, J. H. and *Chiang, C. S. The roles of macrophages and nitric oxide in interleukin-3-enhanced HSV-sr39tk-mediated prodrug therapy. PLoS One 8(2):e56508. , 2013 (Feb. 18). IF: 3.730 (7/56 in MULTIDISPLINARY SCIENCES)

  53. Chen, J. J., Fu, S. Y., Chiang, C. S., Hong, J. H. and *Yeh, J. K. Characterization of tumor vasculature distributions in central and peripheral regions based on Doppler ultrasound. Medical Physics 39(12):7490-7498, 2012 (Dec.). IF: 2.830 (29/116 in RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING)

  54. Wang, T. H., Hsieh, H. A., Hsieh, Y. K., Chiang, C. S, Sun, Y. C. and  *Wang, C. F. The in vivo biodistribution and fate of CdSe quantum dots  in the murine model: a laser ablation inductively coupled plasma mass spectrometry study. Anal. Bioanal. Chem. 404 (10): 3025-3036, 2012 (Dec.) IF: 3.778 (13/73 in CHEMISTRY, ANALYTICAL)

  55. Luo, W.Y., Shih, Y.S., Hung, C.L., Chiang, C. S., Lo, W.H., Huang, S.F., Wang, S.C., Yu, C.F., Chien, C.H. and *Hu, Y.C.. Development of the hybrid Sleeping Beauty-baculovirus vector for sustained gene expression and cancer therapy. Gene Therapy 19 (8): 844-851 ,2012 (Aug.) . IF: 4.538 (22/160 in BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

  56. *Chiang, C.S., Fu, S.Y., Wang, S. C., Yu, C.F., Chen, F.H., Lin, C.M. and Hong, J.H. Irradiation promotes an M2 macrophage phenotype in tumor hypoxia. Front. Oncol.  2: 89-100, 2012 (Aug). (doi: 10.3389/fonc). IF: 4.416

  57. Li, C.Y., Chiang, C.S., Cheng, W.C., Wang, S.C., Cheng, H.T., Chen, C.R., Shu, W.Y., Tsai, M.L., Hseu, R.S., Chang, C.W., Huang, C.Y., Fang,.S.H. and *Hsu, I.C. Gene Expression Profiling of Dendritic Cells in Different Physiological Stages under Cordyceps sinensis Treatment. PLoS One 7(7):e40824, 2012 (Jul). IF: 3.534 (8/55 in MULTIDISPLINARY SCIENCES)

  58. Huang, H. L., Chiang, L. W., Chen, J. R., Yang, W. K., Jeng, K. C., Chen, J. T., Duh, T. S., Lin, W. J., Farn, S. S., Chiang, C. S., Huang, C. W.,  Lin, K. I. and *Yu, C. S. Study of [18F]FLT and [123I]IaraU for cellular imaging in HSV1 tk-transfected murine fibrosarcoma cells: Evaluation of the tracer uptake using 5-fluoro, 5-iodo and 5-iodovinyl arabinosyl uridines as competitive probes. Nucelar Medicine and Biology 39(3): 371-376, 2012 (April). IF:  2.620 (38/113 in RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING)

  59. Lin, K. J., Wu, C. C., Pan, Y. H., Chen, F. H., Fu, S. Y., Chiang, C. S., Hong, J. H. and *Lo, J. M. In vivo imaging of radiation-induced tissue apoptosis by 99mTc(I)-his6-annexin A5. Annals of Nuclear Medicine 26 (3): 272-280, 2012 (April). IF: 1.386 (71/131 in RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING)

  60. Wang, S. C., Hong, J. H., Hsueh, C. and *Chiang, C. S. Tumor-secreted SDF-1 promotes glioma invasiveness and TAM tropism toward hypoxia in a murine astrocytoma model. Laboratory Investigation 92(1): 151-162, 2012 (Jan). IF: 3.641 (14/79 in PATHOLOGY)

  61. Huang, C. L., Shu, W. Y., Tsai, M. L., Chiang, C. S., Chang, C. W., Chang, C. T. and *Hsu, I. C. Repeated small perturbation approach reveals transcriptomic steady states. PLoS One 6(12): e29241, 2011 (Dec.). IF:  4.092 (12/85 in BIOLOGY)

  62. Huang, W. C., Chiang, W. H., Huang, Y. F., Lin, S. C., Shih, Z. F., Chern, C. S., Chiang, C. S. and *Chiu, H. C. Nano-scaled pH-responsive polymeric vesicles for intracellular release of doxorubicin. Journal of Drug Targeting  19(10): 944-953, 2011 (Dec.)  IF:  2.491 (112/252 in PHARMACOLOGY & PHARMACY)

  63. Luo, W.Y., Shih, Y.S., Lo, W.H., Chen, H.R., Wang, S.C., Wang, C.H., Chien, C.H., Chiang, C.S., Chuang, Y.J. and *Hu, Y.C.. Baculovirus vectors for antiangiogenesis-based cancer gene therapy. Cancer Gene Ther. 18 (9): 637-645, 2011 (Sep.)  IF: 3.744 (33/160 in BIOTECHNOLOGY & APPLIED MICROBIOLOGY)

  64. Chen, F. H., Chiang, C. S., Wang, C. C., Fu, S. F., Tsai, C. S., Jung, S. M., Wen, C. J. Lee, C. C. and *Hong, J. H. Vasculatures in tumors growing from pre-irradiated tissues: formed by vasculogenesis and resistant to radiation and anti-angiogenic therapy. Int. J. Radiation Oncology Biol. Phys. 80 (5):1512 - 1521, 2011 (Aug) IF: 4.176 (14/121 in RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING)

  65. Chen, J. J., Chen, J. J. J., Chiang, C. S., Hong, J. H. and *Yeh, J. K. Assessment of tumor vasculature for diagnostic and therapeutic applications in a mouse model in vivo using 25-MHz power Doppler imaging. Ultrasonics   51: 925 – 931, 2011 (May). IF:1.599 (7/29 in Acoustics)

  66. Wang, S. C., Wu, C. C., Wei, Y. Y., Hong, J. H. and *Chiang, C. S. Inactivation of ataxia telangiectasia mutated gene can increase intracellular reactive oxygen species levels and alter radiation-induced cell death pathways in human glioma cells. Inter J. Radiat. Biol. 87(4): 432-42, 2011 (Apr)  IF:2.275 (1/35 in NUCLEAR SCIENCE & TECHNOLOGY)

  67. Li, C. Y,.Chao, L. P.,Wang, S. C.,Chang, H. Z., Tsai, M. L., Fang, S. H., Liao, P. C., Ho, C. L., Chen, S. T., Cheng, W. C., Chiang, C. S., Hua, K. F.  and  *Hsu, I. C. Honokiol Inhibits LPS-induced Maturation and Inflammatory Response of Human Monocyte-derived Dendritic Cells J. Cellular Physiology  226(9):2338-49, 2011 (Sep.) IF: 4.217 (13/77 in PHYSIOLOGY)

  68. *Hwang, K. C., Lai, P. D., Chiang, C. S.,Wang, P. J. and Yuan, J. J. Neutron Capture Nuclei-Containing Carbon Nanoparticles for Destruction of Cancer Cells. Biomaterials  31(32):8419 -25, 2010. IF: 8.557  (1/32 in MATERIALS SCIENCE, BIOMATERIALS)

  69. Yang, T.S., Cuin, Y., Wu, C. M., Lo, J. M., Chiang, C. S., Shu, W. Y., Chung, W. J.,  Yu, C. S., Chiang, K. N. and *Hsu, I. C. Determining the Zero-Force Binding Energetics of Intercalated DNA Complex Using Single Molecule Approach. ChemPhysChem. 10(16):2791-2794, 2009 (Nov.). IF:3.5 (2/32 in PHYSICS, ATOMIC, MOLECULAR & CHEMICAL)

  70. Li, C. Y., Chiang, C. S., Tsai, M. L., Hseu, R. S., Shu, W. Y., Sun, Y. C., Chang, Y. S., Lin, J. G., Chen, C. S., Chuang, C. Y. and *Hsu, I. C. Two-sided effect of Cordyceps sinensis on dendritic cells in different physiological stages. J. Leu. Biol. 85(6):987-995,  2009 (June). IF: 4.605 (23/121 in IMMUNOLOGY)

  71. Tsai, M. L., Chang, K. Y., Chiang, C. S., Shu, W. Y., Weng, T. C., Chen, C. R., Lin, H. K.,Huang, C. L. and *Hsu, I. C. UVB induces persistent activation of ribosome and oxidative phosphorylation pathways. Radiat. Res. 171 (6): 716-724, 2009 (June).  IF: 3.043 (14/72 in BIOLOGY)

  72. Sun, W.L. , Yu, C.F. , Chiang, L.W., Yu, C. S., Chiang, C. S., Lee, T. W. and *Lo, J. M. Evaluation of 5-123I-Iodo-arabino-uridine([123I]IaraU) as a Gene Probe for Tramp-C1/HSV1-sr39tk System. Ann. Nucl. Med. Sci. (ISBN: 1022-923X), 22 (1): 25-33, 2009 (March)

  73. Chen, F. H., Chiang, C. S., Wang, C. C., Tsai, C.S., Jung, S. M., Lee, C. C., McBride,W. H. and *Hong, J. H. Radiotherapy decreases vascular density and causes hypoxia with macrophage aggregation in TRAMP-C1 prostate tumors. Clinic. Cancer Res. 15 (5):1721 – 1729, 2009 (March). IF: 8.193 (13/202 in Oncology)

  74. Chang, I. P., *Hwang, K. C. and Chiang, C. S. Preparation of fluorescent magnetic nanodiamonds and cellular iImaging. J. Am. Chem. Soc. 130(46):15476-15481, 2008 (Nov.).  IF: 8.091 (7/127)

  75. Liu, W. C., Chuang, W. L., Tsai, M. L., Hong, J. H., McBride, W. H. and *Chiang, C. S. Cordyceps sinensis health supplement enhances recovery from taxol-induced leucopenia. Exp. Bio. Med. 233(4): 447-455, 2008 (April). IF: 2.526 (48/112 in Medicine, Research & Experimental)

  76. *Chiang, C. S., Chen, F. H., Hong, J. H., Jiang, P.S., Huang, H. L., Wang, C. C. and McBride, W. H. Functional phenotype of macrophages depends on assay procedures. International Immunology 20(2):215-222) , 2008 (Feb.). IF: 3.181 (46/121)

  77. Chiang, C. S., Yu, C. F., Chiang, L. W., Chen, S. W., Lo, J. M. and *Yu, C. S. Comparison of bioactivities of 5-fluoro, 5-iodo, 5-iodovinyl, and 5-fluorovinyl arabinosyl uridines against SR-39 TK-transfected murine prostate cancer cells. Chem. Pharm. Bull. 56 (1): 109-111, 2008 (Jan)

  78. Tsai ,C.S., Chen, F.H., Wang, C.C., Huang, H.L., Jung, S. M., Wu, C. J., Lee, C. C., McBride, H. W., Chiang, C. S. and *Hong, J. H. Macrophages from irradiated tumors express higher levels of inos, arginase-I and cox-2, and promote tumor growth. Int. J. Radiation Oncology Biol. Phys. 68(2):499-507, 2007 (June) IF: 4.639 (7/92)

  79. Liu, W.C., Wang, S.C., Tsai, M.L., Chen, M.C., Wang, Y.C., Hong, J.H., McBride, W.H. and *Chiang, C.S. Protection against radiation-induced bone marrow and intestinal injuries by Cordyceps sinensis - a Chinese herbal medicine. Radiation Research. 166(6):900-907, 2006 (Dec.) IF: 3.043 (14/72 in BIOLOGY)

  80. Tsai, C.H., Hong, J.H., Hsieh, K.F., Hsiao, H.W., Chuang, W.L., Lee, C.C., McBride, W.H. and *Chiang, C.S. Tetracycline-regulated intratumoral expression of interleukin-3 enhances the efficacy of radiation therapy for murine prostate cancer.  Cancer Gene Therapy. 13 (12):1082-1092, 2006 (Dec.) IF: 4.187(36/144)

  81. Chiang, C.S., Liu, W.C.,Jung, S.M., Chen, F.H.,Wu, C.R., McBride, W.H., Lee, C.C. and *Hong, J.H. Compartmental responses after thoracic irradiation of mice: strain differences.  Int. J. Radiation Oncology Biol. Phys. 62 (3):862–871, 2005, IF: 4.639 (7/90)

  82. *Henke, A., Chiang, C.S, Zell, R. and Stelzner, A. Co-expression of interleukin-2 to increase the efficacy of DNA vaccine-mediated protection in coxsackievirus B3-infected mice. Antiviral Res. 64(2):131-136, 2004 (Nov.)

  83. *McBride, W. H., Chiang, C. S., Olson, J. L., Wang, C. C., Hong, J. H., Pajonk, F., Dougherty, G. J., Iwamoto, K. S., Pervan, M. and Liao, Y. P. A sense of danger from radiation. Radiat. Res. 162 (1):1 – 19, 2004 (July)

  84. Hong, J. H., Jung, S. M. , Tsao, T. C. Y., Wu, C. J., Lee, C. Y., Chen, F. H., Hsu, C. H., McBride, W. H. and *Chiang, C. S.  Bronchoalveolar lavage and interstitial cells have different roles in radiation-induced lung injury. Inter. J. Radiat. Biol. 79 (3): 159-167, 2003 (March)

  85. *McBride, W. H., Pajonk, F., Chiang, C. S. and Sun, J. R. NF-kappa B, cytokines, proteasomes, and low-dose radiation exposure. Mil. Med. 167 (2 Supp): 66 – 67, 2002 (Feb.)

  86. Daigle, J. L., Hong, J. H., Chiang, C. S. and *McBride, W. H. The Role of Tumor Necrosis Factor Signaling Pathways in the Response of Murine Brain to Irradiation. Cancer Research 61: 8859 – 8865, 2001 (Dec.)

  87. Hong, J. H., Chiang, C. S., Tsao, C. Y., Lin, P. Y., Wu. C. R. and *McBride, W. H. Can short-term administration of dexamethason abrogate radiation-induced acute cytokine gene response in lung and modify subsequent molecular responses?  Int. J. Radiat. Oncol. Biol. Phys. 51:296-303, 2001(Oct.)

  88. Daigle, J. L., Chiang, C. S. and *McBride, W. H. Radiation-induced gene expression in brain. Jpn J. Cancer Clin. 47 (1): 27 – 30, 2001 (Jan.)

  89. Wu, Y. Z., Hong, J. H., Huang, H. H., Dougherty, J. G., McBride, W. H. and *Chiang, C. S. Mechanisms mediating the effects of IL-3 gene expression on tumor growth.  J. Leukocyte Biology 68(6): 890-896, 2000 (Dec.)

  90. *Chiang, C. S., Hong, J. H., Wu, Y. C., McBride, H. W. and Dougherty, J. G. Combining radiation therapy with IL-3 gene immunotherapy. Cancer Gene Therapy, 7(8) 1172-1178, 2000 (Aug)

  91. *Hong, J. H., Chiang, C. S., Tsao, C. Y., Lin, P. Y., McBride, W. H. and Wu, C. J. Rapid induction of cytokine gene expression in lung after single and fractionated doses of radiation. International Journal of Radiation Biology 75:1421-1427,1999 (Nov.)

  92. Powell, H. C., Garrett, R. S., Brett, F. M., Chiang, C. S., Chen, E., Masliah, E. and *Campbell, I. L. Response of glia, mast cells and the blood brain barrier, in trasgenic mice expressing interleukin-3 in astrocytes, an experimental model for CNS demyelination.  Brain Pathology 9:219-236, 1999 (Apr.)

  93. Chiang, C. S., Sawyers, C. L. and *McBride, W. H. Oncogene expression and cellular radiation resistance: A modulatory role of c-myc. Molecular Diagnosis 3(1): 21-29, 1998 (March)

  94. Chiang, C. S., Syljuåsen, R. G., Hong, J. H.,Wallis, A., Dougherty, G. J. and *McBride, W. H. Effect of IL-3 gene transduction on tumor response to irradiation in vitro and in vivo. Cancer Res. 57(18): 3899-3903, 1997 (Sep.). IF: 7.856 (12/196 in Oncology)

  95. Stalder, A. K., Pagenstecher, A., Yu, N. C., Kincaid, C., Chiang, C. S., Hobbs, M. V., Bloom, F. E. and *Campbell, I. L. Lipopolysaccharide induced interleukin-12 expression in the CNS and cultured astrocytes and microglia. J. of Immunology 159 (15): 1344-1351 , 1997 (Aug.)

  96. Chiang, C. S., Hong, J. H., Stalder, A., Sun, J. R., Withers, H. R. and *McBride, W. H.. Delayed molecular responses to brain irradiation. Inter. J. Radiat. Biol. 72 (1):45-53., 1997 (July)

  97. Campbell, I. L., Stalder, A. K., Chiang, C. S., Steffensen, S., Henriksen, S., Bellinger, B.,Siggins, G.,Heyser, C.,Masliah, E., Powell, H. and *Gold, L. H. Transgenic models to assess the pathogenic actions of cytokines in the central nervous system. Mol. Psychiatry 2(2):125-129, 1997 (March).

  98. Hong, J. H., Chiang, C. S., Sun, J. R., Withers, H. R. and *McBride, W. H. Induction of c-fos and jun -B mRNA following in vivo brain irradiation. Molecular Brain Research 48 (2): 223-228, 1997

  99. Gold, L. H., Heyser, C.J., Roberts, A.J., Henriksen, S.J., Steffensen, S.C., Siggins, G.R., Bellinger, F.P., Chiang, C. S., Powell, H.C. and *Masliah, E. Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice. Adv. Exp. Med. Biol., 402:199-205, 1996

  100. McBride, W. H., Economou, J. S., Syljuasen, R., Parrish, C., Hackman, D., Latham, V., Chiang, C. S. and *Dougherty, G. J. The effects of cytokine gene tranfer into tumor on host cell infiltration and regression. Anticancer Res. 16: 1139-1144, 1996

  101. Chiang, C. S., Samimi, A., Powell, H. C., Gold, L. and *Campbell, I. L. Macrophage/microglia-mediated primary demyelination and motor disease induced by the CNS production of interleukin-3 in transgenic mice. J. Clinc. Invest. 97: 1512 - 1524, 1996 .

  102. *McBride, W. H., Economou, J. S., Kuber, N., Hong, J. H., Chiang, C. S., Syljuasen, R. G., Dougherty, S. T. and Dougherty, G. J. Modification of tumor microenviroment by cytokine gene transfer. Acta Oncol. 34(3):447-451, 1995

  103. Hong, J. H., Chiang, C. S., Campbell, I. L., Withers, H. R. and *McBride, W. H. Induction of acute-phase gene-expression by brain irradiation. Int. J. Radiat. Oncol. Biol. Phys. 33:619-626, 1995

  104. *Campbell, I. L. and Chiang, C. S. Cytokine involvement in CNS disease: implications from transgenic mice. Ann. N.Y. Acad. Sci. 771: 310-312, 1995

  105. McBride, W. H., Dougherty, G. D., Wallis, A. E., Economou, J. S. and *Chiang, C. S. Interleukin-3 in gene therapy of cancer. Folia Biol.  40: 62-73, 1994.

  106. Hong, J. H., Gatti, R. A., Huo, Y. K., Chiang, C. S. and *McBride, W. H. G2/M-phase arrest and release in ataxia telangiectasia and normal cells after exposure to ionizing radiation. Radiat Res.  140: 17-23, 1994.

  107. Chiang, C. S., Stalder, A., Samimi, A. and *Campbell, I. L. Reactive gliosis as a consequence of interleukin-6 expression in the brain: studies in transgenic mice. Dev Neurosci.  16: 212-21, 1994.

  108. *Campbell, I. L., Samimi, A. and Chiang, C. S. Expression of the inducible nitric oxide synthase. Correlation with neuropathology and clinical features in mice with lymphocytic choriomeningitis. J Immunol.  153: 3622-9, 1994.

  109. Mason, K. A, *Withers, H. R. and Chiang, C. S. Late effects of radiation on the lumbar spinal cord of guinea pigs: re-treatment tolerance. Int J Radiat Oncol Biol Phys. 26(4):643-648, 1993

  110. Chiang, C. S., McBride, W. H. and *Withers, H. R. Myelin-associated changes in mouse brain following irradiation, Radiother Oncol.  27: 229-36, 1993

  111. Chiang, C. S., McBride, W. H. and *Withers, H. R. Radiation-induced astrocytic and microglial responses in mouse brain. Radiother Oncol.  29: 60-8, 1993.

  112. Chiang, C. S., Mason, K. A., Withers, H. R. and *McBride, W. H. Alteration in myelin-associated proteins following spinal cord irradiation in guinea pigs [see comments]. Int J Radiat Oncol Biol Phys.  24: 929-37, 1992.

  113. Chiang, C. S. and *McBride, W. H. Radiation enhances tumor necrosis factor alpha production by murine brain cells. Brain Res.  566: 265-9, 1991.

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B. Book Section:

1.    McBride, W. H., Dougherty, G. J., Syljuasen, R., Chiang, C. S., and Daigle, J. L. New molecular and genetic approaches aimed at improving radiation therapy.  In Progress in Radio-Oncology Vol. VI, Kogelnik, H. D., and Seldmayer, F. eds. Monduzi Editore S.p. A. – Bologna (Italy), pp. 27-33, 1998

2.    McBride, W. H., Chiang, C. S., Hong, J. H., and Withers, H. R. Molecular and celluar responses of the brain to radiotherapy. In Progress in Anti-Cancer Chemotherapy, Vol. 1 Khayat, D. and Hortobagyi, G. N. eds. Blackwell Science Ltd. MA, Chap. 6, pp.91 – 132, 1997

3.    Gold, L. H., Heyser, C. H., Roberts, A. J., Henriksen, S. J., Steffensen, S. C., Siggins, G. R., Bellinger, F. P., Chiang, C. S., Powell, H. C., Masliah, E., and Campbell, I. L. Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice.  In AIDS, Drugs of Abuse, and the Neuroimmune Axis, Friedmann et all eds.  Plenum Press, New York, Chap. 26. pp. 199 – 205, 1996

4.    Chiang, C. S., Dougherty, G. J., Economou, J. S. and McBride, W. H. Tumor-directd cytokine gene therapy. In Gene therapy - from laboratory to the clinic, K. M. Hui, eds. World Scientific Publishing Co. Pte. Ltd., New Jersey, pp. 20-44. 1994

5.    McBride, W. H. and Chiang, C. S. The response of normal brain tissue to irradiation. In Stereotatctic surgery and radiosurgery, A. A. F. De Salles and S. J. Goetsch, eds. Medical Physics Publishing, Wisconsin, pp. 159-167. 1993

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